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For Healthcare Professionals

2011 Articles of Interest: 

• Nutritional and Metabolic Status of Children with Autism vs. Neurotypical Children, and the Association with Autism Severity. 
  Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, Gehn E, Loresto M, Mitchell J, Atwood S, Barnhouse S, Lee W. Nutrition & Metabolism 2011, 8:34 doi:10.1186/1743-7075-8-34.  Published: 8 June 2011.
  "The autism group had many statistically significant differences in their nutritional and metabolic status, including biomarkers indicative of vitamin insufficiency, increased oxidative stress, reduced capacity for energy transport, sulfation and detoxification. Several of the biomarker groups were significantly associated with variations in the severity of autism. These nutritional and metabolic differences are generally in agreement with other published results and are likely amenable to nutritional supplementation. Research investigating treatment and its relationship to the co-morbidities and etiology of autism is warranted."
  
• Prenatal vitamins, one-carbon metabolism gene variants and risk for autism. Schmidt, RJ, RL Hansen, J Hartiala, H Allayee, LC Schmidt, DC Tracredi, F Tassone and I Hertz-Picciotto. 2011.  Epidemiology: July 2011 - Volume 22 - Issue 4 - pp 476-485.
• Dietary Choline Intake by Children with Autism Is below the Recommended Dietary Reference Intake (DRI) Established by the IOM.James, SJ, Pauly M, Melnyk S, Stewart PA, Schmidt BL, Lemcke N, Reynolds AM, Molloy CA, Johnson C, Clemons T, Hyman SL.International Meeting for Autism Research (IMFAR) 2011 May 12. 
  “The low dietary intake of choline and betaine in children with autism may contribute to reduced methylation capacity in some children with autism.”
  
• Nutrient Intake and Supplement Use In Children with Autism Spectrum Disorders: Do Multivitamins Provide the Nutrients Consumed In Low Amounts? Stewart PA, Schmidt BL, Lemcke N, Wixom N, Clemons T, Peck R, Foley J, Hyman SL.  International Meeting for Autism Research (IMFAR) 2011 May 12. 
  “Many children with ASD do not meet recommended intakes for nutrients.”
  
• Glutathione Redox Imbalance and Increased DNA Oxidation In Specific Brain Regions In Autism. Chauhan A,  Audhya T,  Chauhan V. International Meeting for Autism Research (IMFAR) 2011 May 12. 
  “A decrease in reduced glutathione (GSH), an increase in its oxidized form (GSSG) and a decrease in redox ratio of GSH/GSSG in cerebellum and temporal cortex in autism subjects, but not in other brain regions suggest brain region-specific glutathione redox imbalance in autism. Increase in DNA oxidation in frontal cortex, temporal cortex and cerebellum in autism but not in parietal and occipital cortex further confirms that oxidative stress differentially affects selective brain regions in autism. These results indicate increased oxidative damage coupled with reduced antioxidant status in the brain of individuals with autism.”
  
• A Randomized Controlled Double-Blind Trila of N-Acetylcysteine in Children with Autism. Hardan AY,  Fung LK, Libove RA, Obukhanych VT, Nair S, Frazier WT, Herzenberg L, Tirouvanziam R.   International Meeting for Autism Research (IMFAR) 2011 May 12. 
  “NAC was overall well-tolerated with limited side effects. Compared to placebo, NAC resulted in significant improvements in overall aberrant behaviors and irritability.” “Data from this pilot investigation suggest that NAC is a safe and potentially effective in treating irritability and disruptive behaviors in children with autism.”
  
• Homocysteine level in urine of autistic and healthy children. Kałużna-Czaplińska J, Michalska M, Rynkowski J.Acta Biochim Pol. 2011 Mar 11.
  "The higher level of homocysteine in autistic children may indicate deficiencies of folic acid and vitamins B6 and B12 in nutrition of these children."
  
• Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shimmura C, Kawai S, Yoshihara Y, Wakuda T, Takebayashi K, Takagai S, Matsumoto K, Tsuchiya KJ, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Mori N. PLoS One. 2011;6(5):e20470. Epub 2011 May 27.

 

2010 Articles of Interest: 

• Level of Trace Elements (Copper, Zinc, Magnesium and Selenium) and Toxic Elements (Lead and Mercury) in the Hair and Nail of Children with Autism.  Priya L, Geetha A. Biol Trace Elem Res. 2010 Jul 13.
  
• Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder. Bradstreet JJ, Smith S, Baral M, Rossignol DA. Altern Med Rev 2010 Apr;15(1):15-32.
  
• Urinary Porphyrin Excretion in Neurotypical and Autistic Children. Woods JS, Armel SE, Fulton DI, Allen J, Wessels K, Simmonds PL, Granpeesheh D, Mumper E, Bradstreet JJ, Echeverria D, Heyer NJ, Rooney JP.   Environ Health Perspect 2010 Jun 24.  
• Micronutrients versus standard medication management in Autism: A Naturalistic Case-Control Study. Mehl-Madrona L, Leung B, Kennedy C, Paul S, Kaplan BJ.  J Child Adolesc Psychpharmacol. 2010 Apr; 20(2):95-103. 
  "the micronutrient group's improvement was significantly greater" "There are some advantages to treatment with micronutrients - lower activity level, less social withdrawal, less anger, better spontaneity with the examiner, less irritability, lower intensity of self-injurious behaviors, markedly fewer adverse events, and less weight gain."
• A preliminary study on nutritional status and intake in Chinese children with autism. Xia W, Zhou Y, Sun C, Wang J, Wu L.  Eur J Pediatrics 2010 Apr 27.
  "It is therefore important that children with autism should be regularly monitored for nutritional status and dietary intake.  In addition, parents and guardians of autistic children should be provided with accurate nutritional information and should be encouraged to diversify the diet of their child or otherwise rectify the deficiencies identified here through appropriate supplementation with vitamins and minerals."
  
• Food selectivity and sensory sensitivity in children with autism spectrum disorders. Cermak SA, Curtin C, Bandini LG. J Am Diet Assoc. 2010 Feb;110(2):238-46. 
  
• A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder. Kern JK, Geier DA, Adams JB, Geier MR.   Biometals. 2010 Jun 9.
  
• Chromium, cadmium, and lead levels in urine of children with autism and typically developing controls. Yorbik O, Kurt I, Haşimi A, Oztürk O., Biol Trace Elem Res. 2010 Jun;135(1-3):10-5. Epub 2009 Aug 18. 

 

2009 Articles of Interest: 

• Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW.  Am J Clin Nutr. 2009 Jan;89(1):425-30.
  
• Does nutritional intake differ between children with autism spectrum disorders and children with typical development? Herndon AC, DiGuiseppi C, Johnson SL, Leiferman J, Reynolds A.  J Autism Dev Disord. 2009 Feb;39(2):212-22. Epub 2008 Jul 4.

2008 Articles of Interest:

• Dietary intake and parents' perception of mealtime behaviors in preschool-age children with autism spectrum disorder and in typically developing children.  Lockner DW, Crowe TK, Skipper BJ.   J Am Diet Assoc. 2008 Aug;108(8):1360-3.
  
• Altered amino acid excretion in children with autism. Evans C, Dunstan RH, Rothkirch T, Roberts TK, Reichelt KL, Cosford R, Deed G, Ellis LB, Sparkes DL.   Nutr Neurosci. 2008 Feb;11(1):9-17.  
  
• Nutritional therapies for mental disorders. Lakhan SE, Vieira KF. Nutr J. 2008 Jan 21;7:2.
• A prospective study of transsulfuration biomarkers in autistic disorders. Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, Geier MR.   Neurochem Res. 2009 Feb;34(2):386-93. Epub 2008 Jul 9.  
  
• Nutritional and environmental approaches to preventing and treating autism and attention deficit hyperactivity disorder (ADHD): a review. Curtis LT, Patel K.  J Altern Complement Med. 2008 Jan-Feb;14(1):79-85.

 

• Previous Articles of Interest:

• Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. Adams JB, Holloway C.  J Altern Complement Med. 2004 Dec;10(6):1033-9. 
• Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. Adams JB, Holloway C. J Altern Complement Med. 2004 Dec;10(6):1033-9. 
• Plasma amino acid levels in children with autism and their families..  Aldred S, et al. J Autism Dev Disord. 2003 Feb;33(1):93-7.  
  
• Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies.  Arnold GL et al. J Autism Dev Disord 2003 33(4):449-54.  
  
• The essentials of calcium, magnesium and phosphate metabolism: part I. Baker SB, Worthley LI.  Physiology. Crit Care Resusc. 2002 Dec;4(4):301-6.  
• Rational dosages of nutrients have a prolonged effect on learning disabilities. Carlton R et al.  Alternative Therapies2000; 6:85-91. 
  
• Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA.    Am J Clin Nutr. 2004 Dec;80(6):1611-7. 
  
• Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. II.  Pervasive developmental disorder-autism. Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP. Magnes Res. 2006 Mar;19(1):53-62. 
  
• Magnesium VitB6 intake reduces central nervous system hyperexcitability in children. Mousain-Bosc M, Roche M, Rapin J, Bali JP.  J Am Coll Nutr. 2004 Oct;23(5):545S-548S.  
• The effect of vitamin-mineral supplementation on the intelligence of American schoolchildren: a randomized, double-blind, placebo-controlled trial. Shoenthaler S et al.J Altern Complement Med 2000;6:19-29. 
  
• Reduced violent behavior following biochemical therapy. Walsh WJ, et al.  Physiol Behav. 2004 Oct 15;82(5):835-9.
  
• Spot urinary creatinine excretion in pervasive developmental disorders. Whiteley P, et al.  Pediatr Int. 2006 Jun;48(3):292-7.  

James B. Adams, Ph.D, researcher at Arizona State University, conducted the clinical studies on Syndion. Dr. Adams is not affiliated with Yasoo Health and does not benefit financially from Syndion sales.  Click to visit Dr. Adams's research website.